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<p class="ql-align-justify">Ulcerated mucosal fragments are infiltrated by an invasive malignant epithelial neoplasm of squamous origin, organized in irregular nests, cords, and solid sheets. The neoplastic cells exhibit marked nuclear pleomorphism, hyperchromasia, and prominent eosinophilic nucleoli with active mitosis. Focal keratinization is identified. The stroma demonstrates desmoplastic response associated with a dense lymphoplasmacytic infiltrate and foci of tumor necrosis.</p>
<p class="ql-align-justify">Diabetic female patient presenting with a one-month history of a non-healing mandibular extraction socket, swelling, alveolar bone resorption, and mobility of adjacent teeth,?? osteomyelitis.</p>
<p class="ql-align-justify">Four soft tissue fragments collectively measured 1.5x1x0.7 cm, including one tooth.</p>
<p><strong><em><u>Alveolar margin lesion, biopsy:</u></em></strong></p><ul><li><strong>Squamous Cell Carcinoma, moderately differentiated (G2). </strong></li></ul><p><br></p><h5><strong>Comment</strong></h5><h5 class="ql-align-justify">Given the reported clinical evidence of bone resorption, this lesion carries significant staging implications; under the AJCC 8th Edition, invasion through the cortical bone into the medullary space classifies the primary tumor as T4a, regardless of surface diameter. Immediate oncological staging via contrast-enhanced imaging (CT/MRI) and clinical neck examination is essential to assess for regional lymph node metastasis.</h5>
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