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<p class="ql-align-justify">Sections reveal partially ulcerated mucosal fragments infiltrated by an invasive moderately differentiated adenocarcinoma. The tumor is composed of crowded, irregular, and angulated glands exhibiting fused and back-to-back architecture with minimal intervening stroma. These neoplastic structures are set within a desmoplastic background and are lined by atypical epithelial cells demonstrating nuclear enlargement, hyperchromasia, pleomorphism, loss of polarity, and prominent nucleoli.</p>
<p class="ql-align-justify">Dysphagia and heartburn. Endoscopy: multiple irregular nodules started at 25 cm below the dental arch and extends downwards, the largest is about 3 cm and irregular infiltrative circumferential tumor growth started at 30 cm from gastroesophageal junction, this growth extending down to the cardia with severe luminal narrowing. On background of previous barrettes esophagus.</p>
<p>Two biopsies were received:</p><p class="ql-align-justify">1- Esophageal biopsy: soft tissue fragments collectively measured 0.5 cm, totally embedded.</p><p class="ql-align-justify">2- Gastroesophageal junction biopsy: soft tissue fragments collectively measured 1 cm, totally embedded.</p>
<p><strong><em><u>Gastroesophageal junction mass, endoscopic biopsy:</u></em></strong></p><ul><li><strong>Tubular adenocarcinoma, grade 2.</strong></li></ul><p><strong>COMMENT </strong></p><h5 class="ql-align-justify"><strong>The tumor may have originated from Barrett’s esophagus or extended from the gastric cardia.</strong></h5>
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