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<p class="ql-align-justify">A crateriform, exo-endophytic squamous proliferation with a central keratin plug and peripheral epidermal lipping. The underlying dermis contains broad, pushing nests of well-differentiated atypical squamous cells exhibiting mild anaplasia and mitotic activity, glassy eosinophilic cytoplasm, and extensive keratin pearls, set within a chronic inflammatory infiltrate. Margins of excision are free.</p><h3><strong>PATHOLOGY TUMOR SUMMARY:</strong></h3><ul><li><strong>Specimen:</strong> Excision.</li><li><strong>Tumor Site:</strong> Right infra-orbital cheek.</li><li><strong>Macroscopic Appearance: </strong>Ulcerated mass.</li><li><strong>Tumor Size:</strong> 1.8 x 1.7 cm.</li><li><strong>Histologic Type:</strong> Squamous cell carcinoma, keratoacanthoma type (Keratoacanthoma).</li><li><strong>Histologic Grade:</strong> Well-differentiated.</li><li><strong>Margins:</strong> Uninvolved by tumor (Distance to closest margin: 0.1 cm; Maximum margin: 0.7 cm).</li><li><strong>Lymphovascular Invasion:</strong> Not identified.</li><li><strong>Perineural Invasion:</strong> Not identified.</li></ul>
<p class="ql-align-justify">Rapidly growing, nodular ulcerative lesion on the right infra-orbital cheek.</p>
<p class="ql-align-justify">The received specimen consists of a skin ellipse measuring 3 x 2.8 x 1 cm, showing a gray-colored, ulcerated mass measured 1.8 x 1.7 cm. <em> </em>Surgical margins ranged from 0.1 cm to 0.7 cm.</p>
<p><strong><em><u>Right infra-orbital cheek mass, excision:</u></em></strong></p><ul><li><strong>Keratoacanthoma (well-differentiated squamous cell carcinoma, keratoacanthoma type).</strong></li></ul>
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