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<p class="ql-align-justify">Extensively ulcerated esophageal mucosal fragments are infiltrated by nests and sheets of malignant squamous epithelial cells. The neoplastic cells exhibit enlarged, pleomorphic, hyperchromatic nuclei with prominent nucleoli and moderate-to-abundant eosinophilic cytoplasm. Focal individual cell keratinization is noted. Mitosis is active. The surrounding stroma shows a desmoplastic reaction and a chronic inflammatory infiltrate.</p>
<p>Upper esophageal deep large ulcer</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 0.9 cm, totally embedded.</p>
<p class="ql-align-justify"><strong><em><u>Upper Esophageal Ulcer, Endoscopic Biopsy:</u></em></strong></p><ul><li class="ql-align-justify"><strong>Squamous Cell Carcinoma, Moderately Differentiated (Grade 2).</strong></li></ul>
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