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<ul><li><strong>Procedure: </strong>Radical mastectomy.</li><li><strong>Tumor site:</strong> Retroareolar.</li><li><strong>Tumor size (greatest dimension in mm):</strong> 55 mm.</li><li><strong>Histologic type:</strong> Invasive carcinoma (NOS).</li><li><strong>Histologic grade</strong>: grade 2.</li><li><strong>Extension to skin:</strong> Identified, with pagetoid spread of tumor into epidermis and ulceration.</li><li><strong>Chest wall (pectoral muscle) involvement:</strong> Identified.</li><li><strong>Margin status: </strong>Negative.</li><li><strong>Lymphovascular invasion:</strong> Present.</li><li><strong>Perineural invasion:</strong> Not identified .</li><li><strong>Multifocality / multicentricity (number of foci and dimensions):</strong> Unifocal, 5.5 x 5 x 2 cm.</li><li><strong>Presence/extent of DCIS (if concurrent)—grade and extent:</strong> Minor, intermediate grade with lobular cantherization.</li><li><strong>Number of lymph nodes examined (total):</strong> 14 .</li><li>N<strong>umber positive for metastasis:</strong> 14.</li><li><strong>Greatest dimension of lymph nodes</strong>: 30 mm.</li><li><strong>Extra-nodal / extracapsular extension (present/absent):</strong> Present.</li><li><strong>Pathologic stage:</strong> pT3N2Mx.</li></ul><p><br></p><p><br></p><p><br></p><p><br></p>
<p class="ql-align-justify">Neglected, advanced breast cancer that has extended to the skin and infiltrated the underlying muscle.</p>
<p class="ql-align-justify">Received is a left breast specimen measuring 17 x 9.5 x 3 cm, partially covered by an ellipse of skin measuring 14 x 7 cm. The nipple is not identified. An attached axillary tail measures 5.5 x 4 cm. Serial sectioning of the specimen reveals a solid, firm, creamy-colored mass measuring 5.5 x 5 x 2 cm. The mass is infiltrating the skin, located 1 cm from the deep margin, 3.5 cm from the superior margin, 1 cm from the inferior margin, and 2 cm from the medial margin, and 4 cm from the lateral margin. Dissection of the axillary tail yields 14 lymph nodes, the largest of which measures 3 cm in greatest dimension.</p>
<h3><strong><em><u>Modified radical mastectomy:</u></em></strong></h3><ul><li><strong>Invasive carcinoma (NOS), grade 2.</strong></li><li><strong>Stage: pT3N2Mx.</strong></li><li><strong>Margins are negative. </strong></li><li><strong>Lymph nodes are (14/14) positive for metastasis, with extranodal extension. </strong></li></ul>
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