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<p class="ql-align-justify">Sections reveal an extensive inflammatory process within both soft tissue and bone. The soft tissue demonstrates florid granulation tissue, dense reactive fibrosis, hemorrhage, and vascular congestion, accompanied by a prominent mixed acute and chronic inflammatory infiltrate (lymphocytes, plasma cells, histiocytes, and scattered neutrophils). Multinucleated giant cells and osteoclasts are present as a secondary reactive process. The bone fragment shows reactive woven bone rimmed by active osteoblasts within a fibrotic, inflamed marrow space. Focal areas of devitalized bone (sequestrum) with empty osteocytic lacunae and surrounding inflammatory exudate are noted. No evidence of specific granulomas. There is no evidence of malignancy.</p>
<p class="ql-align-justify">Left septic knee and chronic osteomyelitis of the left femur.</p>
<p class="ql-align-justify">Soft tissue pieces measuring 6 x 5 x 1.2 cm in aggregate. Additionally, there is one separate bone fragment measuring 2 x 1.5 cm. All were totally embedded.</p>
<p><strong><em><u>Left knee / Left femur lesion, debridement:</u></em></strong></p><ul><li><strong>chronic suppurative osteomyelitis extending to soft tissue. </strong></li><li><strong>Negative for malignancy. </strong></li></ul>
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