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<p class="ql-align-justify">Skin and deep soft tissue with a keratinized stratified squamous epithelium overlying a dermis containing preserved adnexal structures. The underlying stroma is replaced by dense, disorganized collagenous fibrosis and proliferative granulation tissue, characterized by numerous small-caliber blood vessels. Marked chronic inflammatory infiltrate, composed primarily of lymphocytes and plasma cells, permeates the fibrovascular tissue. Deeper regions exhibit focal areas of ischaemic-type necrosis and fibrinous exudate, consistent with the clinical "dirty tissues" and the presence of a chronic sinus tract. No evidence of specific granulomas. No evidence of atypia or malignancy.</p>
<p class="ql-align-justify">History of chronic left foot infection and osteomyelitis, previously managed with debridement, underwent a left leg amputation. Histopathological evaluation was requested for the amputated bone and associated 'dirty' (necrotic/infected) soft tissues to confirm the extent of the infectious and degenerative process.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 2.5x2.2x1 cm, totally embedded.</p>
<p><strong><em><u>Specimen (fragments from Left Leg Amputation):</u></em></strong></p><ul><li><strong>Chronic Ulcerative Inflammation with Extensive Fibrosis and Dermal Scarring</strong>, <strong>consistent with:</strong></li><li><strong>Chronic Osteomyelitis</strong></li><li><strong>Extensive devitalization.</strong></li><li><strong>Sinus tract formation.</strong></li><li><strong>Negative for malignancy. </strong></li></ul>
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