Tumor shows fascicles of spindle cells separated by loose/myxoid stroma. Cell have rather abundant eosinophilic cytoplasm, vesicular and bland looking nuclei. Anaplasia is mild and mitosis is inactive. No evidence of necrosis . Tumor cells are seen admixed with focal inflammation.
CD34 is diffusely positive.
SMA is focally positive.
ALK is focally positive.
p63 is focally positive.
Desmin is negative.
Myogenin shows non specific cytoplasmic staining.
S-100 is negative.
CK is negative.
Ki-67 is about 5% in hotspots.
Tongue mass.
Submitted one paraffin block. Sections immunostained for SMA, Desmin, Myogenin, ALK, S-100, CD34, p63, CK, Ki-67.
Tongue mass, excision biopsy, referred paraffin block for review and immunostaining:
Superficial CD34-positive fibroblastic tumor (SCPFT), myxoid variant.
COMMENT: