There is near complete loss of the normal nodal pattern and diffuse replacement by atypical population of intermediate non-cleaved lymphoid cells exhibiting single central or multiple peripheral micronucleoli. Anaplasia is moderate and mitosis is active. Picture is suggestive of non-Hodgkin's lymphoma. For confirmation and definitive subtyping, marker study (CD20, CD3, Ki-67) is recommended.
Generalized lymphadenopathy (axillary, cervical, and retroperitoneal), splenomegaly with splenic nodules
Six lymph nodes collectively measured 9.5x7.5x1.7 cm, with the largest measuring 5x4.5x1.7 cm.
Axillary lymph nodes, excision biopsy: