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<p><strong>Specimen:</strong> Left Breast modified radical mastectomy.</p><p><strong>Primary Tumor</strong></p><ul><li><strong>Histologic Type:</strong> Invasive Carcinoma of no Special type (NOS) = Invasive Ductal Carcinoma (IDC).</li><li><strong>Histologic Grade:</strong> Grade 2 (Intermediate grade).</li><li><strong>Tumor Size:</strong> 6.0 cm in greatest dimension.</li><li><strong>Lymphovascular Invasion (LVI):</strong> <strong>Present</strong>.</li><li><strong>Perineural Invasion (PNI):</strong> <strong>Not identified</strong>.</li></ul><p><strong>Margins & Extent</strong></p><ul><li><strong>Surgical Margins:</strong> All margins are <strong>negative</strong> for invasive carcinoma.</li><li class="ql-indent-1">Deep resection margin (1 cm).</li><li><strong>Skin Involvement:</strong> Tumor infiltrates the epidermis with <strong>ulceration</strong>.</li><li><strong>Nipple and Areola:</strong> <strong>Free</strong> of tumor; negative for Paget cells.</li></ul><p><strong>Lymph Nodes</strong></p><ul><li><strong>Total Lymph Nodes Recovered:</strong> 15.</li><li><strong>Number of Positive Nodes:</strong> 0.</li><li><strong>Status:</strong> All 15 nodes are <strong>negative</strong> for malignancy (0/15).</li></ul><h3><strong>Pathologic Staging (AJCC 8th Edition).</strong></h3><ul><li><strong>Primary Tumor (pT):</strong> <strong>pT4b</strong> Due to skin ulceration and infiltration of the epidermis.</li><li><strong>Regional Lymph Nodes (pN):</strong> <strong>pN0</strong> Based on 15 negative nodes.</li><li><strong>Distant Metastasis (M):</strong> <strong>pMx.</strong></li><li><strong>Anatomic Stage Grouping:</strong> <strong>Stage IIIB.</strong></li><li class="ql-align-justify"><strong>Comment:</strong> The presence of skin ulceration upgrades the tumor to a T4 category regardless of size, resulting in an overall Stage IIIB designation despite the absence of lymph node involvement.</li></ul>
<p class="ql-align-justify">Left Modified Radical Mastectomy for Invasive Ductal Carcinoma.</p>
<p class="ql-align-justify">Left modified radical mastectomy: fibrofatty tissue measuring 22 x 11.5 x 4 cm, covered partially by a 17 x 8 cm skin ellipse with unremarkable nipple and areola with an attached axillary tail measuring 8 x 5 x 3 cm. Sectioning reveals an ill-defined, solid, firm, creamy-colored mass measuring 6 x 5.5 x 3 cm located in the medial half. The mass is 1 cm from the deep margin, which is the nearest resection margin, while the superior, inferior, medial, and lateral margins are 3 cm, 1.5 cm, 6.5 cm, and 5 cm away, respectively. The remaining breast tissue shows scattered focal fibrotic changes, and a total of 15 axillary lymph nodes were dissected from the axillary tail, with the largest measuring 1.5 cm.</p>
<h3><strong><em><u>Breast, Left, Modified Radical Mastectomy</u></em>:</strong></h3><ul><li class="ql-align-justify"><strong>Invasive carcinoma of no special type (NST), Grade 2, with skin ulceration. All axillary lymph nodes negative for malignancy (0/15).</strong></li><li class="ql-align-justify"><strong>TNM Stage IIIB</strong></li></ul>
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