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<p><strong><em><u>Specimen 1</u>:</em> </strong>Thyroid Gland, Total Thyroidectomy.</p><ul><li>Histologic type: <strong>Papillary thyroid carcinoma.</strong></li><li>Variant:<strong> Classic with a focal micropapillary component.</strong></li><li>Tumor focality: <strong>Multifocal.</strong></li><li>Tumor site: <strong>Involving both lobes.</strong></li><li>Tumor size (greatest dimension): <strong>2.7 cm.</strong></li><li>Extrathyroidal extension: <strong>Present (tumor extends outside the thyroid capsule into perithyroidal soft tissue; skeletal muscle is not involved).</strong></li><li>Lymphovascular invasion (LVI): <strong>Present.</strong></li><li>Surgical margins: <strong>Negative.</strong></li></ul><p><br></p><p><strong><em><u>Specimen 2:</u></em> </strong>Lymph Node Dissection.</p><ul><li>Lymph node status: <strong>Positive for metastatic papillary thyroid carcinoma in eight (8) of eleven (11) lymph nodes examined (8/11).</strong></li><li>Extranodal extension (ENE): <strong>Present.</strong></li></ul><p><strong>Prognostic Indicators (Grade and Stage):</strong></p><p><strong>1- Histologic grade</strong>: Not conventionally graded (papillary thyroid carcinoma is considered a well-differentiated malignancy, though the micropapillary component is a moderately aggressive feature).</p><p><br></p><p><br></p><p><br></p><p><br></p><p><br></p><p><strong>2- Pathologic stage (pTNM, AJCC 8th edition):</strong></p><ul><li><strong>pT2:</strong> Primary tumor >2 cm but <4 cm in greatest dimension.</li><li><strong>pN1:</strong> Regional lymph node metastasis present (8/11 nodes positive).</li></ul><p><strong>Overall stage:</strong></p><ul><li class="ql-indent-1">Patient is <55 years old: Stage I (Any T, Any N, M0).</li></ul>
<p class="ql-align-justify">The patient presented with huge bilateral cervical lymph nodes extending to the retroclavicular and supraclavicular regions, along with jugular lymph node involvement.</p>
<p>Two specimens were received:</p><p class="ql-align-justify">1- Designated as thyroid: Total thyroid ex to my specimen received as 2 separate lobes; the first lobe measured 3 X 2 X 1.4 cm and on sectioning revealed a whitish, nodular mass measuring 2.7 X 1.3 cm. The second thyroid lobe measured 3.3 X 3 x 1.5 cm and cut section revealed multiple nodules, the largest of which measured 1.2 X 1 cm.</p><p class="ql-align-justify">2- Designated as lymph node dissection: Soft tissue fragments collectively measured 11 X 9.5 X 3.5 cm, largest measured 7 x5 x3. 5 cm; sectioing revealed four nodules, the largest measuring 2.5 X 2 cm. Also received sodt tissue fragments collectively measured 6 x 5x2 cm, largest measured 3.5 x2.8 x 2 cm, having rubbery cut section.</p>
<h3><strong><em><u>Total thyroidectomy and </u></em></strong><u>Lymph Nodes Dissection</u><strong><em><u>:</u></em></strong></h3><ul><li><strong>Papillary thyroid carcinoma, multifocal. Focal micropapillary component present.</strong></li><li><strong>Involves both thyroid lobes. </strong></li><li><strong>Minor extrathyroidal extension present (extends outside the capsule, with no muscular involvement)</strong></li><li><strong>Lymphovascular invasion present.</strong></li><li><strong>Margins: Surgical margins negative for carcinoma.</strong></li><li><strong>Positive for metastasis in 8 out of 11 nodes (8/11); extranodal extension present.</strong></li></ul>
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