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<p><strong>SPECIMEN</strong></p><p>Specimen Type: Excision</p><p>Specimen Size: 5 × 3.5 × 1.8 cm</p><p><strong>TUMOR</strong></p><p>Tumor Site: Not specified</p><p>Histologic Type: Invasive carcinoma of no special type (NST)</p><p>Histologic Grade (Nottingham Combined Histologic Score): Grade 2 (Intermediate)</p><p>Tumor Size: 3.5 × 2.5 × 1.5 cm (Greatest dimension: 3.5 cm)</p><p>Macroscopic Description: Fairly defined solid, firm, creamy-colored mass</p><p><strong>TUMOR-INFILTRATING LYMPHOCYTES (TILs)</strong></p><p>Stromal TILs Percentage: > 50%</p><p>TILs Interpretation: Intermediate to focally high</p><p><strong>DUCTAL CARCINOMA IN SITU (DCIS)</strong></p><p>Presence of DCIS: Present (minor component)</p><p>Architectural Pattern: Solid type</p><p>Nuclear Grade: Intermediate</p><p>Necrosis: Present (comedo type)</p><p>Lobular Cancerization: Present</p><p><strong>ADDITIONAL PATHOLOGIC FINDINGS</strong></p><p>Lymphovascular Invasion (LVI): Present</p><p>Perineural Invasion: not identified</p><p><strong>MARGINS</strong></p><p>Status: Negative for invasive carcinoma and DCIS</p><p>Distance to Closest Margin: 0.3 cm (deep margin)</p><p>Other Margin Distances:</p><p>Superior: 0.5 cm</p><p>Inferior: 0.5 cm</p><p>Medial: 0.5 cm</p><p>Lateral: 1 cm</p><p><strong>PATHOLOGIC STAGING (AJCC 8th Edition)</strong></p><p>Primary Tumor (pT): pT2</p><p>Regional Lymph Nodes (pN): pNX (not assessed)</p>
<p>Lt, breast mass.</p>
<p class="ql-align-justify">Fibrifatty tissue measuring 5 x 3.5 x 1.8 cm. Serial sectioning reveals a fairly defined solid, firm mass that is creamy in color and measured 3.5 x 2.5 x 1.5 cm. The mass is located 0.3 cm from the deep margin, 0.5 cm from the superior margin, 0.5 cm from the inferior margin, 0.5 cm from the medial margin and 1 cm from the lateral margin.</p>
<p><strong><em><u>Breast mass(Left), excision:</u></em></strong></p><ul><li class="ql-align-justify"><strong>Invasive carcinoma of no special type (NST), grade 2;</strong></li><li class="ql-align-justify"><strong>Stromal tumor-infiltrating lymphocytes (TILs): > 50% (intermediate to focally high)</strong></li><li class="ql-align-justify"><strong>Associated with intermediate-grade DCIS (solid type with comedo necrosis and lobular cancerization)</strong></li><li class="ql-align-justify"><strong>Lymphovascular invasion present</strong></li><li class="ql-align-justify"><strong>Margins negative (closest margin: 0.3 cm, deep).</strong></li><li class="ql-align-justify"><strong>pT2Nx</strong></li></ul>
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