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<p class="ql-align-justify">Tissue sections show a cellular astroglial tumor showing fibrillary stroma. Tumor is vascular with evidence of endothelial proliferation with glomeruloid bodies formation. Areas of necrosis are detected. This is a WHO grade 4 tumor. In many foci tumor shows anaplastic cells denoting progression from pre-existing anaplastic astrocytoma.</p>
<p class="ql-align-justify">Headache and visual disturbances was found on MRI to have a large, heterogeneous, solid, and cystic mass in the right frontal lobe measuring 71x36x40mm, associated with surrounding vasogenic edema, restricted diffusion, and a 16mm leftward midline shift, highly suggestive of a high-grade glioma, most likely glioblastoma multiforme.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 6x5x1 cm, totally embedded</p>
<p><strong><u>Rt. frontal lobe mass lesion, biopsy:</u></strong></p><ul><li><strong>Glioblastoma multiforme WHO grade IV, complicating pre-existing anaplastic astrocytoma.</strong></li></ul>
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