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<p class="ql-align-justify">Sections show an infiltrative, hypercellular high-grade tumor with a lobular architecture, composed of pleomorphic spindle to epithelioid cells. These cells display hyperchromasia, prominent nucleoli, and brisk atypical mitoses. The tumor shows biphasic matrix production: disorganized, lace-like osteoid like material is intimately admixed with distinct areas of malignant cartilage. This chondroid component features a basophilic myxoid matrix containing atypical cells within lacunar spaces. Geographic coagulative tumor necrosis is present. Picture is consistent with unclassified spindle cell sarcoma. Marker study (S-100, SOX-10, p63, SMA, SATB2 and KI-67) is recommended for definitive subtyping. </p>
<p class="ql-align-justify">Right-sided facial swelling secondary to a destructive, lytic lesion of the right mandible with cortical erosion and calcifications.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 8x7.5x2.5 cm, the largest measured 4x3.5x2.5 cm.</p>
<p><strong><em><u>Right mandibular bony lesion, excision:</u></em></strong></p><ul><li><strong>Unclassified spindle cell sarcoma.</strong></li><li><strong>Recommended for subtyping by marker study. </strong></li></ul>
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