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<p class="ql-align-justify">The biopsy consists of scanty material formed dominantly of unremarkable fibrofatty tissue with synovial lining with focal tiny fragments of hyperplastic synovium showing mild synoviocyte proliferation and a sparse chronic inflammatory infiltrate. Within the stroma, focal aggregates of hemosiderin-laden macrophages are identified, consistent with the clinical history of chronic effusion. There is no evidence of the diffuse sheet-like growth of mononuclear cells, foamy macrophages, or multinucleated giant cells characteristic of classic Pigmented Villonodular Synovitis (PVNS) in the provided material, and no malignancy is seen.</p>
<p class="ql-align-justify">Chronic knee effusion undergoing arthroscopic evaluation for suspected Pigmented Villonodular Synovitis.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 1x0.8xx0.3 cm, totally embedded.</p>
<p><strong><em><u>Knee joint, synovial biopsy: </u></em></strong></p><ul><li><strong>Chronic non-specific synovitis.</strong></li><li><strong> Negative for malignancy. </strong></li></ul>
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