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<ul><li>Tumor is diffuse positive for CK20, CDX2, SATB2 while negative for PAX8</li><li><span style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">Immunohistochemical staining shows diffuse and strong nuclear expression of MLH1, PMS2, MSH2, and MSH6 in tumor cells, with preserved staining in internal controls (lymphocytes and stromal cells). </span></li><li><span style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">This pattern is consistent with </span><strong style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">proficient MMR status (pMMR)</strong><span style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">; microsatellite-unstable (MSI-H) phenotype is unlikely, and Lynch syndrome is less likely, although not excluded.”</span></li></ul>
<p>Immunostaining of endoscopic biopsy from colonic mass.</p>
<p>Section stained for CK20, CDX2, SATB2, PAX8, <span style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">MLH1, PMS2, MSH2, and MSH6.</span></p>
<p><strong><em><u>Colonic mass, endoscopic biopsy, immunostainings:</u></em></strong></p><ul><li><strong>Adenocarcinoma, grade 2 of colonic primary origin.</strong></li><li><strong style="color: rgb(39, 37, 30); background-color: color(srgb 0.980392 0.972549 0.960784);">Proficient MMR status (pMMR).</strong></li></ul>
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