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<p>Duodenal mucosa showing almost diffuse villous atrophy as the intestinal villi are significantly shrunken or partially flattened (moderate/marked atrophy). The crypts (glands at the base of the villi) become deeper as the body tries to compensate for lost villi. There is a pathological increase in these lymphocytes within the epithelial lining. No evidence of specific granulomas. No evidence of atypia or malignancy.</p>
<p>History of chronic diarrhea with iron deficiency anemia and weight of loss. Duodenal endoscopic biopsy to rule out celiac disease.</p>
<p>Fragments of collective size 6x5 mm.</p>
<p><strong><em><u>Duodenum, Biopsy: </u></em></strong></p><ul><li><strong>Marker villous atrophy, consistent with Marsh Class 3B according to Marsh-Oberhuber classification of celiac disease. </strong></li><li><strong>Associated moderate chronic non-specific inflammation. </strong></li><li><strong>Negative for atypia or malignancy. </strong></li></ul>
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