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<p>Specimen</p><ul><li>Procedure: Abdominoperineal resection (APR) with en bloc partial prostatectomy, Appendectomy.</li><li>Specimen integrity: Intact</li></ul><p>Tumor</p><ul><li>Tumor site: Rectum / rectosigmoid colon</li><li>Histologic type: Adenocarcinoma</li><li>Histologic grade: Grade 2 (moderately differentiated)</li><li>Tumor cellularity: 70%</li><li>Tumor extension: Tumor penetrates the visceral peritoneum and directly infiltrates into the adjacent prostate gland</li></ul><p>Margins</p><ul><li>Proximal margin: Negative for invasive carcinoma</li><li>Distal margin: Negative for invasive carcinoma</li><li>Circumferential resection margin (CRM) / radial margin: Negative for invasive carcinoma</li><li>Prostatic resection margin: Negative for invasive carcinoma</li></ul><p>Lymphovascular and Perineural Invasion</p><ul><li>Lymphovascular invasion (LVI): Present</li><li>Perineural invasion (PNI): Present</li></ul><p>Tumor Budding</p><ul><li>Budding score: Intermediate</li></ul><p>Regional Lymph Nodes</p><ul><li>Total number of lymph nodes examined: 3</li><li>Number of lymph nodes involved: 0 (0 of 3 lymph nodes positive)</li></ul><p>Appendix:</p><ul><li>Free of tumor</li></ul><p>Pathologic Staging (AJCC Cancer Staging, 8th Edition)</p><ul><li>Primary tumor (ypT): ypT4b (tumor directly invades the prostate)</li><li>Regional lymph nodes (ypN): ypN0 (no regional lymph node metastasis identified)</li></ul><p>Therapy Effect (Modified Ryan Tumor Regression Score)</p><ul><li>Tumor Regression Grade (TRG): TRG 2 — Partial response</li><li>Interpretation: Residual adenocarcinoma is present with evident treatment-related changes, including areas of fibrosis consistent with response to neoadjuvant chemoradiotherapy. However, substantial viable tumor remains with persistent invasion into the prostate gland.</li></ul>
<p class="ql-align-justify">Advanced rectal cancer with invasion to prostate status post chemo radiotherapy.</p>
<p>Two specimens were received.</p><ul><li class="ql-align-justify">The first specimen, labeled as recto sigmoid with amputated anus, consisted of a segment of sigmoid colon measuring 23 x 3 x 2 cm associated with attached mesenteric fat measuring 7 x 2 cm. Opening revealed a rubbery solid grey-white mass measuring 3.5 x 2.8 x 2.3 cm, located 2 cm and 17 cm from proximal and distal margins respectively. Mesenetric fat showed thre nodules largest measuring 0.3. Also received separate appendix measuring</li></ul><p class="ql-align-justify">3 x 0.7 cm with attached fat.</p><ul><li class="ql-align-justify">The second specimen, labeled as prostatic pieces: four additional pieces of soft tissue. The aggregate dimensions of the soft tissue pieces measured 5 x 3 x 1.5 cm, with the largest single piece measuring 2.5 x 2 x 1.5 cm.</li></ul>
<p class="ql-align-justify"><strong><em><u>RECTOSIGMOID COLON, ANUS, AND PROSTATE (ABDOMINOPERINEAL RESECTION WITH EN BLOC PARTIAL PROSTATECTOMY):</u></em></strong></p><ul><li><strong>Adenocarcinoma, Grade 2 (moderately differentiated)</strong></li><li><strong>Tumor directly infiltrates the prostate gland</strong></li><li><strong>Status post neoadjuvant chemoradiotherapy</strong></li><li><strong>Modified Ryan Tumor Regression Score (TRG): 2 — Partial response</strong></li></ul>
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