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<p>A papillary tumor formed of fronds covered by non-keratinized stratified squamous epithelium. Core is fibrotic and vascular. No evidence of atypia or malignancy.</p>
<p>One referred paraffin block for PDL-1 of tongue lesion diagnosed as invasive squamous cell carcinoma, well differentiated (previous pathology number 25-N2549).</p>
<p>One referred paraffin block.</p>
<p><strong><u>Tongue lesion, excision, immunostaining:</u></strong></p><ul><li><strong>Benign squamous cell papilloma.</strong></li><li><strong>PD-1 show focal positivity in scattered lymphocytes (internal control) with no significant epithelial expression.</strong></li><li><strong>PDL1- immunostaining shows negative membranous staining for the lesional epithelium CPS<1 (negative).</strong></li><li><strong>Findings do not support significant PD-1/PDL1 axis activation in this lesion. </strong></li></ul>
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