Medical Pathology Report Form

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Sections show a unifocal invasive carcinoma composed of mixed invasive micropapillary and invasive ductal carcinoma, Nottingham histologic grade 2. The invasive tumor measures 2.3 cm in greatest dimension and is characterized by infiltrating nests, cords, and focal micropapillary structures within a desmoplastic stroma. Lymphovascular permeation and perineural invasion are identified. An associated ductal carcinoma in situ (DCIS) component is present, comprising approximately 5% of the tumor volume. The DCIS is of intermediate nuclear grade and shows comedo-type necrosis. All surgical resection margins are free of invasive carcinoma and DCIS. The closest margin is the deep margin, located 0.6 cm from the invasive carcinoma. The grossly described rubbery whitish area reveals intermediate-grade DCIS. The smaller discrete mass measures 1 cm and is consistent with a pericanalicular fibroadenoma. The nipple is involved by lymph vascular emboli and intermediate grade DCIS, but no evidence of Paget disease is identified. Eight axillary lymph nodes are examined, seven of which show metastatic carcinoma. Focal extranodal extension is present.PROCEDUREModified radical mastectomySPECIMEN LATERALITYLeftINVASIVE CARCINOMA<ul><li>Histologic type: Invasive carcinoma of no special type (ductal carcinoma) with mixed invasive micropapillary features</li><li>Tumor focality: Single focus</li><li>Tumor size: 23 mm (2.3 cm)</li><li>Histologic grade (Nottingham)</li></ul>Grade 2 (total score 7) Tubule formation: 3Nuclear pleomorphism: 2Mitotic rate: 2DUCTAL CARCINOMA IN SITU (DCIS)<ul><li>DCIS present: Yes</li><li>Estimated extent: Approximately 5%</li><li>Nuclear grade: Intermediate</li><li>Necrosis: Present, comedo type</li></ul>ADDITIONAL PATHOLOGIC FEATURES<ul><li>Lymphovascular invasion: Present</li><li>Perineural invasion: Present</li><li>Nipple involvement: Not identified</li><li>Paget disease: Not identified</li></ul>MARGINS<ul><li>Margin status (invasive carcinoma):Negative</li><li>Margin status (DCIS): Negative</li><li>Closest margin: Deep (posterior)</li><li>Distance to closest margin: 6 mm (0.6 cm)</li></ul>REGIONAL LYMPH NODES<ul><li>Number examined: 8</li><li>Number positive: 7</li><li>Extranodal extension: Present, focal</li></ul>ADDITIONAL FINDINGS<ul><li>Intermediate-grade ductal carcinoma in situ involving grossly rubbery whitish area (7 × 5 cm)</li><li>Pericanalicular fibroadenoma corresponding to 1 cm lesion</li></ul>PATHOLOGIC STAGE (AJCC 8th edition)<ul><li class="ql-align-justify">pT2 pN2a</li></ul>

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