Fragments of squamous-lined esophageal mucosa with prominent intraepithelial eosinophilia, greatest in the superficial and mid-epithelial layers. Peak counts show multiple foci with ≥15 eosinophils per high-power field (HPF, 400×), with occasional eosinophil microabscesses (clusters of ≥4 eosinophils). There is associated basal cell hyperplasia with expansion of the basal layer, focal elongation of papillae into the upper third of the epithelium, and spongiosis (intercellular edema). Surface epithelial sloughing and scattered degranulated eosinophils are noted. The lamina propria shows a chronic inflammatory infiltrate with variable superficial fibrosis. No evidence of atypia or malignancy in submitted material.
Intermittent dysphagia. Endoscopy revealed esophagitis,? Esinophilic esiphagitis.
Soft tissue fragments collectively measured 0.8x0.5 cm totally embedded.
Esophageal endoscopic biopsy:
COMMENT: