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<p class="ql-align-justify">Focally ulcerated duodenal mucosa showing almost diffuse villous atrophy as the intestinal villi are significantly shrunken or partially flattened (moderate/marked atrophy). The crypts (glands at the base of the villi) become deeper as the body tries to compensate for lost villi. There is a pathological increase in these lymphocytes within the epithelial lining. No evidence of specific granulomas. No evidence of atypia or malignancy.</p>
<p class="ql-align-justify">Hematemesis. Endoscopy: mild atrophic changes and fissuring of the duodenal mucosa.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 0.5 cm, totally embedded.</p>
<p><strong><em><u>Duodenum, Biopsy: </u></em></strong></p><ul><li><strong>Marked villous atrophy, consistent with Marsh Class 3B according to Marsh-Oberhuber classification of celiac disease. </strong></li><li><strong>Associated moderate chronic non-specific inflammation. </strong></li><li><strong>Negative for atypia or malignancy. </strong></li></ul><p class="ql-align-justify"><br></p>
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