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<p class="ql-align-justify">Partialy ulcerated mucosal fragments by related malignant glandular epithelium forming irregular, back-to-back and cribriform glands with focal solid growth. Tumor cells show nuclear pleomorphism, hyperchromasia, prominent nucleoli. Anaplasia and mitoses are moderate. A desmoplastic stromal response is present. Lymphovascular invasion is noted.</p>
<p>Distal common bile duct lesion (ampullary biopsy).</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 0.7x0.5 cm, totally embedded.</p>
<p><strong><em><u>Ampullary lesion, endoscopic biopsy:</u></em></strong></p><ul><li><strong>Adenocarcinoma, moderately differentiated.</strong></li></ul>
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