Thyroid gland shows nodular adenomatous hyperplasia. Nodules are variable in size and composed of small and large crowded follicles full of thick colloid and lined by mature epithelium. Sections from some of the nodules show compact microfollicles devoid of colloid and lined by cuboidal cells separated by delicate vascular stroma. In these follicles nuclei are vesicular and look active but no appreciable mitosis. Stroma shows focal infiltration by lymphocytes. These lymphocytes appear to form lymphoid follicles in some foci but no evidence of related follicular oxyphil change. No evidence of hyperfunction or malignancy. Lymph nodes are reactive.
Multinodular goiter.
Total thyroidectomy specimen consisting of two lobes and an isthmus with intact capsule. The first lobe measured 5.8 x 2.5 x 2 cm and contained three nodules, the largest measuring 2.5 x 2 cm. The second lobe measured 5 x 3 x 2.3 cm and was almost entirely occupied by a 4 x 2.7 cm grey nodule. Isthmus measured 1.5x1 cm.
Thyroid gland, total thyroidectomy: