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<p class="ql-align-justify">1- Duodenal mucosa showing almost diffuse villous atrophy as the intestinal villi are significantly shrunken or partially flattened (moderate/marked atrophy). The crypts (glands at the base of the villi) become deeper as the body tries to compensate for lost villi. There is a pathological increase in these lymphocytes within the epithelial lining. No evidence of specific granulomas. No evidence of atypia or malignancy.</p><p>2- Gastric mucosa showing moderate infiltration by lymphocytes and plasma cells. Neutrophils are seen infiltrating glands thus indicating activity. However, H. pylori characteristic forms are not evident. Focal intestinal metaplasia is seen. There is no evidence of atypia or malignancy.</p>
<p>Gastric and duodenal biopsies.</p>
<p>Two biopsies were received:</p><p class="ql-align-justify">1- Duodenal biopsy: soft tissue fragments collectively measured 0.8 cm,totally embedded.</p><p class="ql-align-justify">2- Gastric biopsy: soft tissue fragments collectively measured 0.5 cm, totally embedded.</p>
<p><strong><em><u>Duodenum, endoscopic biopsy: </u></em></strong></p><ul><li><strong>Marked villous atrophy, consistent with Marsh Class 3B according to Marsh-Oberhuber classification of celiac disease. </strong></li><li><strong>Associated moderate chronic non-specific inflammation. </strong></li><li><strong>Negative for atypia or malignancy. </strong></li></ul><p><br></p><p><strong><em><u>Stomach, endoscopic biopsy:</u></em></strong></p><ul><li><strong>H pylori associated chronic gastritis with moderate inflammatory activity and focal intestinal metaplasia. </strong></li><li><strong>Negative for dysplasia.</strong></li><li><strong>Negative for malignancy. </strong></li></ul>
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