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<p>An astroglial tumor formed of proliferating atypical fibrillary astrocytes exhibiting mild to moderate anaplasia. Cellularity is moderate with focal increase in cellularity. However, obvious mitotic activity is not observed and no evidence of vascular or endothelial proliferation. No evidence of tumor necrosis in the examined blocks. However, in view of imaging findings and focal hypercellularity, marker study (GFAP, IDH1 and Ki67) is needed to exclude a higher grade tumor.</p>
<p class="ql-align-justify">Brain MRI: Intra-axial space-occupying mass seen in the left temporal lobe associated with large vasogenic edema seen in the left temporo-parieto-occipital lobes. Findings are favoring if primarily neoplastic processes ( particularly glioma) than metastasis.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 2.8x2.5x0.6 cm, totally embedded.</p>
<p><strong><u>Left intra-axial temporal lobe mass, biopsy:</u></strong></p><ul><li><strong>Diffuse astrocytoma, WHO grade II, with cellular areas. </strong></li><li><strong>Recommended for maker study to exclude anaplastic transformation.</strong></li></ul>
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