Medical Pathology Report Form

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Clinical Data

Gross Description

Microscopic Description

Diagnosis

Review of the submitted histological sections reveals tissue fragments consistent with ovarian stroma extensively infiltrated by a malignant neoplasm. The tumor demonstrates a diffuse pattern of growth, characterized by non-cohesive individual cells, cords, and focal areas of glandular differentiation. The neoplastic cells exhibit marked cellular pleomorphism with hyperchromatic nuclei and increased mitosis. A significant proportion of the tumor cells display classic signet ring cell morphology, featuring abundant intracytoplasmic mucin vacuoles that displace the nucleus to the periphery. These neoplastic elements are embedded within a desmoplastic stroma. Separate section consistent with omental tissue are composed of mature adipose and fibroconnective tissue. These sections are free of tumor involvement. Immunohistochemical staining was performed on the tumor cells with appropriate positive and negative controls. The neoplastic cells are positive for CK7, CK20, EMA, and CD15. The tumor cells are negative for PAX8, CD10, GATA3, Calretinin, SATB2, and CDX2. The Ki-67 proliferation index is approximately 30 % in tumor cells.

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