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<p class="ql-align-justify">Gastroesophageal junction biopsy reveals partially ulcerated esophageal mucosal fragments by an invasive neoplasm composed of crowded, irregular, and angulated glands infiltrating a desmoplastic stroma. These complex glandular structures demonstrate branching and cribriform patterns and are lined by atypical columnar epithelium characterized by nuclear pleomorphism, hyperchromasia, and loss of polarity. Anaplasia and mitoses are moderate. Adjacent. Gastric mucosa shows chronic active inflammation.</p>
<p class="ql-align-justify">Lower esophageal polypoidal mass extending to the sub-cardia causing luminal stenosis.</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 1 cm, totally embedded.</p>
<p><strong><em><u>Lower esophageal mass, endoscopic biopsy :</u></em></strong>.</p><ul><li><strong>Adenocarcinoma, moderately differentiated. </strong></li></ul><p><br></p><p><strong><u>COMMENT</u></strong></p><h5 class="ql-align-justify">This tumor could be extending from cardia of stomach or it could arising on top of Barrett's esophagitis. Please correlate with endoscopic findings to decide origin of this tumor. </h5>
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