Medical Pathology Report Form

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Clinical Data

Gross Description

Microscopic Description

Diagnosis

Both samples show mature bony trabeculae and intervening marrow spaces that are focally infiltrated by mostly crushed malignant epithelial neoplasm (Block B). The tumor cells are predominantly arranged in distinct solid sheets, cords and single forms. The neoplastic cells exhibit moderate to marked nuclear atypia, characterized by enlarged, pleomorphic, and hyperchromatic nuclei with prominent nucleoli and a moderate amount of eosinophilic to amphophilic cytoplasm. Desmoplastic stromal reaction is noted in the intervening stroma. Picture is consistent with metastatic high grade undifferentiated carcinoma.Given the patient's age, the primary differential diagnosis favors metastatic prostate carcinoma, followed by metastasis from the lung or gastrointestinal tract. The following panel is recommended to confirm the primary origin: PSA NKX3.1, TTF-1, Napsin A, CK7, CK20, and CDX2.

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