Medical Report Preview
✖
Pathology Report System
3
AD
مشرف النظام
Basic Information
Details & Diagnosis
Basic Report Information
Patient Name
Specimen Number
Age
Gender
Male
Female
Ref By
Received Date
Date Reported
Nature of Specimen
Report Status
Not completed
Completed
Clinical Data
Gross Description
Microscopic Description
Diagnosis
<p class="ql-align-justify">Sections show a florid villonodular synovial proliferation with a dense, subsynovial infiltrate. The hypercellular stroma features a mononuclear population of small histiocyte-like cells and larger polygonal cells with eosinophilic cytoplasm. Multinucleated osteoclast-like giant cells and lipid-laden foamy macrophages are interspersed throughout. Prominent intra- and extracellular coarse hemosiderin deposition is present. The stroma exhibits focal fibrosis, cleft-like spaces, and peripheral extension into adjacent mature adipose tissue, lacking significant cytologic atypia, atypical mitoses, or necrosis.</p>
<p class="ql-align-justify">The patient underwent an arthroscopic synovectomy of the left knee, with a tissue sample sent for histopathological examination to investigate a suspected diagnosis of Pigmented Villonodular Synovitis (PVNS).</p>
<p class="ql-align-justify">Soft tissue fragments collectively measured 3x2.5x0.6 cm, totally embedded.</p>
<h3><strong><em><u>Left knee synovectomy:</u></em></strong></h3><ul><li><strong>Diffuse Tenosynovial Giant Cell Tumor (Pigmented Villonodular Synovitis). </strong></li></ul><p><br></p><h5><strong>COMMENT</strong></h5><h5 class="ql-align-justify">According to the current World Health Organization (WHO) Classification of Tumours, the entity traditionally known as Pigmented Villonodular Synovitis (PVNS) is officially designated as a <strong>Diffuse Tenosynovial Giant Cell Tumor (D-TGCT)</strong>.</h5><h5 class="ql-align-justify">It is important to note that the WHO classifies this as a locally aggressive neoplasm with a significant propensity for local recurrence, particularly if surgical synovectomy is incomplete. Furthermore, these tumors are typically driven by a <em>CSF1</em> gene translocation. Mentioning the current WHO terminology is clinically useful, as this underlying <em>CSF1</em> overexpression provides a specific rationale for targeted systemic therapies (such as CSF1R inhibitors) in the event of severe, recurrent, or surgically unresectable disease.</h5>
Choose Image
Remove
Image Width (px)
Image Height (px)
Image Position
Center
Left
Right
Template
With Template
Without a Template
المسافة الفارغة من أعلى الصفحة عند عدم استخدام قالب
Header Space (mm)
Send to Telegram
Sending...
Generate PDF
Update